Pathways linking Alzheimer’s disease risk genes expressed highly in microglia
نویسندگان
چکیده
Neuroimmunology and Neuroinflammation is an open access journal, with focuses on neuroimmunology neuroinflammation research, coverage extending to other basic clinical studies related neuroscience.
منابع مشابه
Salmonella enterica highly expressed genes are disease specific.
During in vitro broth culture, bacterial gene expression is typically dominated by highly expressed factors involved in protein biosynthesis, maturation, and folding, but it is unclear if this also applies to conditions in natural environments. Here, we used a promoter trap strategy with an unstable green fluorescent protein reporter that can be detected in infected mouse tissues to identify 21...
متن کاملPotassium channel Kv1.3 is highly expressed by microglia in human Alzheimer's disease.
Recent genetic studies suggest a central role for innate immunity in Alzheimer's disease (AD) pathogenesis, wherein microglia orchestrate neuroinflammation. Kv1.3, a voltage-gated potassium channel of therapeutic relevance in autoimmunity, is upregulated by activated microglia and mediates amyloid-mediated microglial priming and reactive oxygen species production in vitro. We hypothesized that ...
متن کاملHighly expressed genes in yeast evolve slowly.
tion of these findings is that proteins expressed in many The dataset used in this article consists of the remtissues interact with a greater number of molecules and nants of the ancient genome duplication including 376 may also have to function under widely changing cellugene pairs organized into 55 gene clusters (Wolfe and lar conditions. Hence, high pleiotropic constraints on Shields 1997). ...
متن کاملSelective Effects on Highly Expressed Genes
Many different selective effects on DNA and proteins infl uence the frequency of codons and amino acids in coding sequences. Selection is often stronger on highly expressed genes. Hence, by comparing highand low-expression genes it is possible to distinguish the factors that are selected by evolution. It has been proposed that highly expressed genes should (i) preferentially use codons matching...
متن کاملGenomic evidence for elevated mutation rates in highly expressed genes.
Reporter gene assays have demonstrated both transcription-associated mutagenesis (TAM) and transcription-coupled repair, but the net impact of transcription on mutation rate remains unclear, especially at the genomic scale. Using comparative genomics of related species as well as mutation accumulation lines, we show in yeast that the rate of point mutation in a gene increases with the expressio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuroimmunology and neuroinflammation
سال: 2021
ISSN: ['2332-7812']
DOI: https://doi.org/10.20517/2347-8659.2020.60